GASDERMIN AND ITS ROLE IN PYROPTOSIS

The gasdermin family (GSDMs) contains a group of uncharacterized proteins that form membrane pores and serve as major substrate for inflammatory caspases the execution pyroptosis, which is recognized novel type programmed cell death [1]. Gasdermin (GSDM) consists A (GSDMA), B (GSDMB), C GSDMC), D (GSDMD), E(GSDME) Pejvakin (PJVK). With exception PJVK, all GSDMs consist two conserved domains: C-terminal inhibitory domain (RD) N-terminal effector (PFD), where cytotoxic, while full-length structure It not indicating C-terminus protein (GSDMs-C) has auto-inhibitory protective effects [2]. Because presence C-terminus, GSDM does cause if it cleaved. Once RD removed by hydrolysis, its PFD can combine with lipid components to in [3]. Current studies have found that, except domains almost ability plasma membrane. Among GSDMs, only mechanism GSDMD-induced pyroptosis relatively clear.